The main pharmaco-therapeutic effects: uterotonichna, the ability to stimulate the bodies that have smooth muscles and internal organs modulate response to various hormonal stimuli. and more ). cent. Prostaglandins. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, headache, dizziness, tinnitus, rare - hallucinations, vascular spasm, disturbance of extremities, increased blood pressure, tachycardia (sometimes - bradycardia), shortness of breath. Indications for use drugs: induction of labor in women with mature or nearly full-term pregnancy; gel is used for softening (ripening) of cervix, if necessary, induction of labor activity by medical or obstetrical indications. Contraindications to the use of drugs: hypersensitivity to dilators, multiple pregnancy, women who had 6 or more pregnancies; nevstavlennya head of the here in the Bipolar Affective Disorder canal, cesarean or other uterine surgeries in history, with head size mismatch fetal pelvis mother at the change in heart rate obstetric conditions in which the ratio of benefit and risk to mother and fetus demonstrated the benefits of surgery, pathological (including - blood) discharge from genital tract unknown etiology during pregnancy; netim'yane presentation of the fetus. Indications for use drugs: Abortion in second trimester in these cases - the Unfinished spontaneous abortion, fetal death in uterus, grave violations of growth retardation, inborn Minnesota Multiphasic Personality Inventory disorders that are incompatible with life, which are defined by current diagnostic procedures, artificial abortion when it is impossible because of the risk of complications in the mother during his holding (to the second trimester); local treatment of severe bleeding at pislyapolohoviyi placental stage. Method of production of drugs: Mr injection 0,02% 1 ml in amp. Side effects and complications in the use of drugs: the mother - hypertension, embolism pulmonary embolism amniotic fluid, cardiac arrest, abnormal contraction cauldron here uterus (increased cauldron duration or tone), cauldron rupture, rapid dilatation of cauldron cervix, placenta abruption, nausea, vomiting, diarrhea, raising t ° (fever), back pain, bronchospasm, asthma, rash, Non-squamous-cell carcinoma reactions, transitory vazovazalni symptoms (hot flashes, tremor, headache, dizziness), tissue irritation at the injection cauldron - erythema, increasing the number of cauldron in the blood in fruit - distress-with-m and HR violations, reducing the assessment by Apgar score, mertvonarodzhuvanist, neonatal death. Dosing and Administration of drugs: drug prescribed for adults / m or i / v; dosing regime - an individual, single dose of parenteral injection of 0,1 - 0,2 mg (0,5 - 1 ml) higher dose - 1 mg (5 ml) injecting be combined with internal cauldron erhometrynu maleate, the duration of application is defined clinical effect and tolerability of the drug. Method of production of drugs: infusion concentrate, 1 mg / ml to 0.75 ml in amp., Vaginal gel and 3 g (1 mg).
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